The Ntziachristos laboratory studies the mechanistic aspects of oncogenesis with an emphasis on transcriptional and epigenetic regulation of acute leukemia. We study how oncogenes interact with each other and with epigenetic modulators to influence gene expression programs as well as how their function is related to tri-dimensional (3D) structure of the nucleus and other biological aspects of cancer cells, like metabolism. Recent studies by our group focus on how active deubiquitination controls aspects of oncogenesis and leads to drug resistance in leukemia. To address these questions we use high-throughput molecular and cell biology techniques like RNA-Seq, ChIP-Seq, 4C-Seq and HiC, fluorescent in situ hybridization, biochemical analysis e.t.c., in cell lines and primary cells of human origin and tissues of mouse models of disease. In addition to understanding cancer biology these finding help us design and test targeted therapies in preclinical models of leukemia.
Highly-motivated and collaborative scientists, that hold a Bachelor, Master’s or Ph.D. degree, and with a strong track record and expertize in Bioinformatics, with a focus on RNA biology and the analysis of splicing phenomena, computational systems biology or related fields are encouraged to apply. The candidates should have knowledge of gene expression biology and of high-throughput methodologies such as RNA-Seq, ChIP-Seq, HiC, and 4C-Seq. Successful candidates will be part of a multidisciplinary team and will be part of projects sought out to understand oncogenic function in leukemia.
The group is a member of the Department of Biochemistry and Molecular Genetics situated in the campus of Feinberg School of Medicine in Northwestern University in the heart of the Chicago metropolitan area. The team has access to cutting-edge technology and facilities and is exposed to the vibrant scientific community of Northwestern University and other research centers in the Chicago area. Scientists in the group have the opportunity to present their work and get feedback in Institutional, National and International forums.
The appointment offers competitive salary and generous benefits and the position can be initiated effective immediately. Applicants should submit a cover letter, their curriculum vitae and contact details for at least two referees to panos.ntz@northwestern.edu or pntziachr@gmail.com